Atenolol is a cardio selective β-blocker, widely used in the management of hypertension. The present research work shows a relatively simple method to design and develop control release hydrogels base Atenolol microspheres drug delivery system. The hydrogels base microparticles can be prepared by using solvent evaporation technique which mainly depends on the nature and quantity of the polymer used, the drug, the quantity of emulsifier as well as cross linker like Polyvinyl Alcohol and the duration of the therapy. In the present research work, a Control release Atenolol microparticles synthesized by solvent evaporation method in which the different concentration ranges of biodegradable polymer like Polycaprolactone and an emulsifier like Polyvinyl Alcohol was taken while the amount of Atenolol was taken standard throughout the study. The formulated microspheres were also evaluated for their drug loading properties, swelling index and in vitro drug release which was justified by mathematical models like factorial design studies.
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